Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings
نویسندگان
چکیده
منابع مشابه
Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings.
The functional success of a biomedical implant critically depends on its stable bonding with the host tissue. Aseptic implant loosening accounts for more than half of all joint replacement failures. Various materials, including metals and plastic, confer mechanical integrity to the device, but often these materials are not suitable for direct integration with the host tissue, which leads to imp...
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Harnessing the synergy between materials at the nanoscale can be a valuable tool in understanding and probing cellular phenomena and in driving specific processes that lead to tissue and organ regeneration and repair. Biomedical implants attempt to materially replace damaged tissues, restore function, improve mobility, and alleviate pain. However, these implants often fail to recapitulate the o...
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The interaction between implant material and surrounding tissues is believed to play a fundamental role in implant success. Although bone sialoprotein (BSP) has been found to be osteoinductive when coated onto femoral implants, collagen and fibronectin are the most used compounds for preparation of pre-coated cell culture slides at present. In this study, the support of BSP-, collagen- and fibr...
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Surface patterns can emerge during growth of anisotropic tissues because of surface buckling. This morphogenetic scenario is examined in the present paper based on a simple phenomenological theory of tissue growth. In particular, we show that constrained growth can lead to tissue compression, which in turn may result in surface buckling of the tissue. The latter means the appearance of wavy pat...
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The concept of bone tissue engineering, which began in the early 1980s, has seen tremendous growth in the numbers of research studies. One of the key areas of research has been in the field of implant surgery, where the challenge is to produce the perfect tissue-engineered bone construct. This practical review summarizes applied state-of-the-art research in the important translational research ...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2013
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3005576